Recycled two-stage estimation in nonlinear mixed effects regression models

We consider a re-sampling scheme for estimation of the population parameters in mixed-effects nonlinear regression models type used, example, clinical pharmacokinetics. provide two-stage procedure which resamples (or recycles), via random weightings, various parameter's estimates to construct consistent their respective sampling distributions. In particular, we establish under rather general distribution-free assumptions, asymptotic normality and consistency standard resampled version demonstrate applicability our proposed resampling methodology small simulation study. A detailed example based on real pharmacokinetic data is also provided.